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123I-MIBG Scintigraphy Utility as a biomarker for Prodromal Dementia with Lewy Bodies (SUPErB)

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Why is this study important?

The project hopes to aid early detection of Dementia with Lewy Bodies (DLB) by finding more effective methods of measuring the early changes associated with very early memory problems. This would enable clinicians to diagnose and treat the disorder earlier and more efficiently.

What is the aim of this study?

This study aims to examine the symptoms and brain changes which are associated with very early memory problems. We call this early period the prodromal phase, and by studying these very early changes we can detect and diagnose problems earlier.

What do people in this study have to do?

  • Visit 1
    • Patient’s home
    • Consent & Neurocognitive assessment
  • Visit 2
    • CARU at Newcastle University
    • Diagnostic interview, Medical examination & Neuropsychiatric assessment
  • Visit 3
    • RVI/Freeman Hospital
    • MIBG Scan
  • Visit 4
    • RVI/Freeman Hospital
    • SPECT Scan
  • Visit 5
    • Newcastle University MR Centre
    • 3-Tesla MRI Scan & EEG
    • Optional lumbar puncture

There will then be annual follow ups for 4 years consisting of repeat baseline neurocognitive and neuropsychiatric assessments, a clinical interview and diagnostic assessment.

Recruitment is due to end …


A summary of the study findings should be available by…


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