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Hand Eczema Phototherapy Study

Research Summary:

This study aims to compare two types of phototherapy for patients with hand eczema. 76 participants will be randomised to two groups: Group 1 will receive narrow band UVB phototherapy to the hands. Hands will be exposed to UVB light. Group 2 will receive PUVA phototherapy to the hands. Hands will be soaked in a diluted solution of Psoralen and the exposed to UVA light. Participants will be adults over 18 years of age who have been referred for PUVA treatment to the Royal Victoria Infirmary, Newcastle. Some previous research has suggested that narrow band UVB light treatment may be as effective for hand eczema as PUVA.

Therefore this pilot study will assess the feasibility and refine the methodology for a large multicentre study of PUVA vs narrowband UVB for the treatment of hand eczema. Specifically we will look at the recruitment, retention and response rates of patients. Also test the integrity of the study protocol and pilot the collection of the primary and secondary outcome measures.

Inclusion Criteria:

  • Patient has provided written informed consent for participation in the study prior to any study specific procedures
    • Palmar eczema not responding to topical treatments
    • Over 18 years of age
    • No topical treatments (except emollients for 48 hours)
    • No systemic treatments for eczema treatment for 3 months
    • Absence of clinical evidence of bacterial, fungal or viral infection
    • Not pregnant

Exclusion Criteria:

  • Inability to give informed consent.
    • Significant eczema on the dorsal surface of the hands
    • Previous phototherapy within the last 3 months
    • Previous sunbed use within the last 3 months
    • Current involvement in other investigational studies or trials, or involvement within 3 months prior to study entry

Closed to Recruitment – study is now in follow up

Study Contact – Claire Macdonald

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