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Injuries and Emergencies

Clinical trials in Injuries and Emergencies are improving treatment and services for people in our region. Injuries and emergencies research encompasses an extensive range of conditions. They are all characterised by the fact that they require prompt diagnosis and treatment if the patients are to have the best outcome.

Sometimes these are real emergencies requiring immediate intervention from the paramedics on site which is known as “pre-hospital care”. Other times they are urgent and need rapid treatment in the Emergency Department or Trauma Operating rooms to give the patient the best chance of recovery.

This means that we support and oversee a wide range of research studies. Examples range from “major trauma” in road accidents or falls, burns, anaphylaxis (serious allergic reaction), asthma attack, and cardiac arrest, through to carbon monoxide poisoning, broken bones and sports injuries. In addition, this specialty area also includes some aspects of recovery and rehabilitation after injury, which takes place in a non-emergency setting.

Clinical trials in the North East and North Cumbria

Here is a hyperlink to view the national portfolio of studies many of which are recruiting in the North East and North Cumbria

UK Clinical Trials Gateway

If you are interested in getting involved in I&E research you can click on the ‘Get Involved’ button on this website and register your interest.

Meet the Team

Mr Paul Baker

The Specialty Clinical Lead for the Network is Mr Paul Baker, Consultant Orthopaedic Surgeon based at South Tees NHS Foundation Trust

Dr Lucksy Kottam

Career Scientist in Orthopaedics and Patient and Public Involvement link for Injuries and Emergencies based at South Tees NHS Foundation Trust

Clinical Trials in Injuries and Emergencies

Select a trial from the list below to find out more about what it’s all about and how you can get involved in helping others.

Haemorrhage Alleviation with Tranexamic Acid [HALT-IT]:

The HALT-IT trial will determine the effect of early administration of tranexamic acid on mortality, morbidity (re-bleeding, non-fatal vascular events), blood transfusion, surgical intervention and health status in patients with acute gastrointestinal bleeding

CRASH-3: Tranexamic Acid for the Treatment of Significant Traumatic Brain Injury

The aim of CRASH-3 trial is to establish whether early administration of tranexamic acid reduces the rates of death, disability and vascular occlusive events in adult patients with admitted to hospital with a traumatic brain injury.

WOLLF:

This study looks at the effectiveness of Negative pressure wound therapy (NPWT) with standard dressings for the prevention of infection in patients presenting to hospital with an open fractures of the lower limb.

Patient Perceptions of Multiple Rib fracture rehabilitation:

This study aims to explore the patient perspective of the current issues surrounding recovery and rehabilitation after traumatic multiple rib fractures.

WHiTE Cohort

The aim of this study is to evaluate the use of PROMs in the context of the National Hip Fracture Audit

WHIST: Wound Healing in Surgery for Trauma. A Randomised Controlled trial of standard wound management versus negative pressure wound therapy in the treatment of adult patients having surgical incisions for major trauma to the lower limb.

The aim of the pragmatic RCT is to compare standard dressings with negative wound therapy for treatment of surgical incisions associated with major trauma of the lower limb.

WHiTE4: A randomised controlled trial of the sliding hip screw versus X-Bolt dynamic plating system for the fixation of trochanteric fractures of the hip.

To investigating the patients’ quality of life after X-Bolt (XB) Dynamic Plating System compared with the Sliding Hip Screw (SHS) in the treatment of trochanteric fracture of the hip.

UK FROST: Multi-centre randomised controlled trial with economic evaluation and nested qualitative study comparing early structured physiotherapy versus manipulation under anaesthesia versus arthroscopic capsular release for patients referred to secondary care with a frozen shoulder (Adhesive Capsulitis)

UK FROST is a multi-centre randomised controlled trial with economic evaluation and nested qualitative study comparing early structured physiotherapy versus manipulation under anesthesia versus arthroscopic capsular release for patients referred to secondary care with a frozen shoulder

GEKO: Neuromuscular electrostimulation (NMES) device, pilot feasibility study looking at time to surgery study in patients requiring ankle fixation following fracture, comparison to matched retrospective controls.

The aim of the study is to show that recruiting, and performing study assessments in ankle fracture patients requiring ORIF attending James Cook University Hospital is feasible, and to obtain data to support the powering of a larger study to demonstrate the effectiveness of the GEKO device at reducing length of stay in hospital for this population of patients.


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