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A phase III multi-centre randomised, double blind, placebo controlled trial to assess the role of intravenous immunoglobulin in the management of children with encephalitis (The IgNiTE study)

What is this study about?

There is some evidence that a treatment called intravenous immunoglobulin (IVIg) may benefit children with encephalitis. However, the evidence is based on a small number of children and in some cases only studied children with certain types of encephalitis. There are no research studies that have looked at the effect of IVIg when used in a large number of children, regardless of the type of encephalitis that they have. Also, although some doctors may use IVIg to treat children with encephalitis, this is often given late in the illness so we do not know the effect of IVIg when used early after diagnosis.

In this study, we would like to find out whether IVIg can help children with encephalitis get better quicker if given early during the hospital admission. To do this we want to compare the recovery of children who receive IVIg to those who do not.

Please email Fiona if you would like to know more –

Clinical Trials in Research for Children

Select a trial from the list below to find out more about what it’s all about and how you can get involved in helping others.


This research study aims to find the relationship between the gene mutations associated with ARCI and the observable characteristics and traits of individuals affected by ARCI.


The British Orthopaedic Surgery Surveillance (BOSS) Study is a nationwide reporting mechanism to determine the epidemiology and outcomes in rare orthopaedic diseases.


Should children and young people with long lasting seizures be treated with a medicine called phenytoin or levetiracetam in an emergency setting.


A trial to assess the role of intravenous immunoglobulin in the management of children with encephalitis

Genetic Determinants of Kawasaki Disease

An investigation into Kawasaki Disease by looking at the variation of genes involved in the immune system.


The purpose of this study is to test the effectiveness of home-based light therapy using hand-held units and topical steroid for the treatment of vitiligo.


To evaluate the effectiveness of a six day course of daily prednisoline therapy at the time of URTI in reducing the development of subsequent nephrotic syndrome relapse in children with relapsing SSNS.

Registry (RaDaR)

An initiative by UK kidney specialists to pull together information from patients who have certain rare kidney diseases.


This study has been designed to find out whether it is better to give patients with Cystic Fibrosis antibiotics orally or intravenously.

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