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A large randomised controlled trial in which women undergoing surgery for endometriosis will be randomly allocated to take long acting progestogens

Contact email: f.yelnoorkar@nhs.net

Endometriosis is a common condition where cells similar to those within the lining of the womb are found in abnormal locations elsewhere in the body, commonly within the pelvis. Like the lining of the womb itself, these cells go through a phase of growth followed by breakdown and bleeding. This internal bleeding within the pelvis causes inflammation, the formation of scar tissue (adhesions) and is associated with pain.

Endometriosis occurs in 6-10% of women of reproductive age. The condition is painful and can have a serious impact on their lives. Many will need surgery to remove areas of endometriosis in order to relieve pain. However, symptoms of endometriosis tend to return and women need to go through repeated surgery including removal of their womb and ovaries.

Previous research has suggested that medicines containing female hormones (progestogens) can reduce the chances of symptoms returning. Treatments in this class are contraceptives and include a coil, injections, or the pill. However, these studies were done with small numbers of participants and were unable to provide definitive results. We now wish to carry out a large randomised controlled trial in which women undergoing surgery for endometriosis will be randomly allocated to take long acting progestogens (either as three monthly injections or as a coil, which is inserted into the womb where is remains for five years), or long term treatment with the oral contraceptive pill, or no treatment.  This information will be vital in terms of future clinical decision making in an area of uncertainty.

Read more about this trial here: http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=16166

Link to Endometriosis UK  http://www.endometriosis-uk.org/news/participants-needed-pre-empt-clinical-trial-37315

Link to Trial Team page at Birmingham University http://www.birmingham.ac.uk/research/activity/mds/trials/bctu/trials/womens/pre-empt/index.aspx

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Here you can access journal articles from research carried out here in our region

PRE-EMPT

A large randomised controlled trial in which women undergoing surgery for endometriosis will be randomly allocated to take long acting progestogens. The trial will provide information on which treatment is the most effective in terms of symptom relief, side-effects, acceptability and costs.

CONCEPTT

CONCEPTT: Continuous Glucose Monitoring in Women with Type 1 Diabetes in Pregnancy Trial


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